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Larry Gold

Chairman and Founder, SomaLogic
Professor of Molecular, Cellular and Developmental Biology
University of Colorado Boulder

The Gold lab began with basic research on bacteria and bacteriophage, then shifted focus to human disease following the invention of the SELEX process in 1989. SELEX (Systematic Evolution of Ligands by Exponential enrichment) is a combinatorial chemistry methodology in which vast numbers of oligonucleotides (DNA, RNA, or unnatural compounds) are screened rapidly for specific sequences that have appropriate binding affinities and specificities toward any target. SELEX also has been used to identify new ribozymes and deoxyribozymes. The Gold Lab currently focuses on the utilization of biological and information technology to improve healthcare.

 

"From Sol Spiegelman to modern SELEX (with help from Harold B White III)"

SELEX and aptamers were described by Craig Tuerk and Andy Ellington in nearly simultaneous papers in 1990.  Over the next three decades we came to appreciate how the early and provocative work of Sol Spiegelman and Hal White made the richness of SELEX easy to understand in an evolutionary context.  More than 10,000 papers have been published aimed at broadening the functional possibilities for aptamers and SOMAmers, and yet one keeps reading and rereading the papers of Spiegelman and White for inspiration.  Besides sharing the richness of the writing and thinking from those “early” days I will show some modern applications of aptamer-based proteomics research for healthcare.

 

Larry Gold